HT Physical Organic Chemistry

Despite the increasing number of techniques in the perspective of fast preparation of chemical entities, screening steps often represent the bottleneck of high throughput techniques. Analytical processes are often time consuming and require a set of instruments since no universal characterisation tool is currently available. Amongst those tools, Electrospray Ionisation Mass Spectrometry (ESI/MS) has the advantage of being fast and compatible with automatisation, but it has two main drawbacks of not sensitive compounds and not being quantitative. To address these loopholes, a specific MS Tag is currently being developed, that can allow systematic detection and quantitative studies on mixtures of products by single ESI/MS analysis. Many applications can then be developed around the concept: Monomers reactivity profiling has been achieved and Hammett parameters assessment is currently investigated. Other applications are planned.