Dr. John Ellard

Dr. Jeff Thaburet

Jeff was born in Rouen in Normandie, the town where Joan of Arc was burnt. He obtained a technical diploma (DUT) in Chemistry in 1989 and then started studying Chemistry at the University of Rouen in 1990. In 1994, he graduated from the engineering school, INSA, and began his PhD funded by the Roquette Freres company (subject: the oxidation of starch hydrolysed products). He graduated in 1998 and worked during 1999 as a postdoc in the field of lubricants for the company, IGOL, synthesising peresters of sugars. During spring 2000, he joined the Bradley group for a second postdoc. His current subject is the evaluation of the efficiency of new solid supported catalysts. Outside the lab, he likes picking up mushrooms, cooking and practising tennis, gymnastics and mountain biking. He has a keen interest in supporting the Olympique de Marseille in football and likes watching the English rugby team losing. He enjoys tasting wines, particularly French such as meursault, champagne or côte rotie. He also loves cinema, as well as old films, as recent.

Dr. Saraj Ulhaq

Dr Saraj obtained his PhD in Dec.1997 from University of Bath. He worked on Nitric Oxide Synthase inhibitors, as anticancer agents. Following this, he did a short term Post-Doc at Manchester University, working on hypoxia selective anti-cancer drugs. Saraj moved to beautiful Canada for 2 years at the University of Regina, Saskatchewan. In August 2000, he joined Professor Bradley’s group, to battle against parasitic diseases such as Trypanosomes and Leishmanias. He is using the revolutionary techniques of combinatorial chemistry, high-throughput screening and molecular modelling to quickly identify antiparasitic drug candidates. His love for science has allowed him to gain valuable experience in medicinal chemistry. He is an expert in wide range of organic synthetic techniques, conventional and modern, wide range of protein purification techniques as well as enzyme kinetic studies. He is a very good lecturer and supervisor. Outside the lab, Saraj enjoys the great outdoors. He likes Cycling, Camping, Fishing etc. He is also quite an expert at Indian Cookery. A well rounded CHAP.

Dr. Zhanru Yu

Zhanru was born and grew up in China. He received his Bachelors and Masters degrees from Nankai University in Tianjin of PR China. After, he worked on Polymer Chemistry in the Institute of Polymer Chemistry at this University. In 1991 he joined the group of Prof. Dr. Josep Castells and Dr. Francisco Lopez-Calahorra in the Department of Organic Chemistry, Faculty of Chemistry, University of Barcelona. His work was concerned with Polymer-supported Organic Reactions and reagents. Subsequently, he started a Ph.D. studying under the direction of Prof. Dr. Dolores Velasco on Liquid crystal Polymers, again in the same group. As of` March of 1999, he has been working for Prof. Dr. Mark Bradley at the University of Southampton. His research involves the search for new solid organic synthesis supports.
Out of work, he is keen on football, but only watch. He likes almost all sports and sometimes plays volleyball and tennis. Since his son was born, two years ago, he has found that he wants to play with him as much as possible.

Dr. Butrus Atrash

Butrus Atrash was born in Lebanon in 1954. He obtained his B.Sc. in Chemistry in 1977 from the American University of Beirut, Lebanon. He received his M.Sc. in Petrochemicals and Hydrocarbon Chemistry in 1978 and his Ph.D. in 1981 both from the University of Manchester Institute of Science and Technology, UK. His Ph.D. research was carried out under the supervision of Professor R Ramage and involved the use of organophosphorus compounds in peptide synthesis. Between 1981 and 1986, he worked as a senior research chemist at the Department of Chemical Pathology, Hammersmith Hospital, University of London. His work involved the design, synthesis and isolation of biologically active peptides, mainly renin and thrombin inhibitors. This work was in close collaboration with Ferring AB of Sweden. This work culminated in the discovery of nanomolar enzyme inhibitors.
Between 1986 and 1996, he worked with Professor Michael Szelke at the Ferring Research Institute, Southampton, UK. This work involved the identification of enzyme inhibitors in medicinal chemistry research and covered a broad range of projects. Since 1996, he has been working with Professor Mark Bradley at the Chemistry Department of the University of Southampton. The work is concerned with solid phase, combinatorial and peptide chemistry. Progress has already been made in the discovery of a pH cleavable linker for zone diffusion assays and which is 'biocompatible' (Butrus Atrash and Mark Bradley, Chem. Commun., 1997. 1397).

José A Bravo was born and educated as a chemist in Oviedo (Spain). After completing his degree in Chemistry, he spent one year at the University of Aberdeen working under the supervision of Dr James A Wardell in the synthesis of metallo-derivatives of carbohydrates. He moved to Birmingham in 1995 to start his Ph.D in the laboratories of Prof. J Fraser Stoddart whom he followed to UCLA (USA) in 1997. His doctoral investigations were centered on the template-directed syntheses of mechanically-interlocked compounds, being his major achievement the self-assembly of a rotacatenane, a novel type of molecule which resembles both a catenane and a rotaxane. In December 1998 he joined Prof. Mark Bradley research group where he works on the solid phase synthesis of new libraries and new screening methodologies. His main activity outside the lab is salsa dancing.

Dr. Mike Davies

Current position: Team Leader - Combinatorial Chemistry at Celltech Therapeutics, 216 Bath Road, Slough, Berkshire, SL1 4EN, UK. High speed synthesis and combinatorial chemistry in drug discovery, primarily directed at the areas of integrin inhibition (VLA-4, AvB3 and A1B7) and Kinase inhibition (KDR). We are also interested in the implementation of new technologies and development of methodologies and to enhance our efforts in these areas. PhD in natural product synthesis with Prof E. J. Thomas at Manchester. Research interests: Preparation of novel phosphate ester prodrugs as potential therapies for HIV. Use of novel reporter groups in the synthesis of oligonucleotides for use in PCR applications (Past). Solid phase and combinatorial chemistry including synthesis and applications of 'inverted' and C-terminally modified peptides. Host guest chemistry. Novel coding strategies for use in solid phase synthesis and developing new analytical techniques for application in combinatorial chemistry (with Mark Bradley).

Dr. Christophe Fromont

Christophe passed his 1st and 2nd cycle at University of "Sciences and Technologies of Lille", France. He then moved to Calvados at the University of Caen (Laboratoire de Chimie Moleculaire et Thio-organique) to prepare a DEA (Diplome d'Etudes Approfondies) with Dr Patrick Metzner. There, he studied a thioclaisen rearrangement stereo controlled by an adjacent chiral sulfur centre1,2. After his national service in the 46th infantry regiment in Berlin, Germany (which he really enjoyed) he joined Dr Serge Masson's group (LCMT) to prepare his PhD on both the synthesis and reactivity (nucleophilic and electrophilic additions) of new N-Phenyl silylated ketenimines3. He was awarded his PhD in December 1997 and joined Prof. Bradley's group in January 1998. His first research project was the introduction of dye molecules into a target guest for the libraries screening prepared by Vincent Pomel (supra-molecular recognition chemistry). He then investigated the generation of high loading beads. Christophe now works for Ribotargets in Cambridge.

Fabrice Guillier was born in 1968 in the city of Saint Denis, France. He received the diplome d'Ingénieur chimiste in 1992 from the National Institute of Applied Sciences (INSA Rouen) after studying chemical engineering and fine organic chemistry. In 1996 he completed a Ph.D. thesis on natural products synthesis using metallation and cross-coupling reactions in the laboratories of Prof. Guy Quéguiner (URA1429-IRCOF-Rouen-France). These methodologies using palladium and lithium derivatives were suitable to achieve the synthesis of polyheterocyclic marine alkaloids of the pyridoacridine family. He then spent one year as postdoctoral fellow at Southampton University, working with Prof. Jeremy Kilburn (Dept. Chemistry, Univ. of Southampton-UK) studying the synthesis and supramolecular interactions of guanidinium based tweezer receptors for C-terminal tripeptides. From 1997 to 1999 he joined the research group of Prof. Mark Bradley at the University of Southampton where he conducted research on development of new methods for screening on solid support. Currently he is working on solution phase parallel synthesis as a post-doctoral research associate in the combinatorial chemistry technology group in the Alanex division at Agouron Pharmaceuticals (San Diego-USA).

He moved from Agouron Pharmaceuticals in 2000 to Strasbourg in France for the creation of  Euroclide S.A a spin off from University Louis Pasteur based on FRET based Assay Development for Orpghan GPCR. He then moved to Fournier Pharma in Dijon France in 2003 were I am in charge of the Parallel Synthesis and Combinatorial Chemistry Group wher he still occupy this position. Fournier Pharma was acquired by Solvay Pharmaceuticals in July 2005.

Originally from 'up North', via Durham (B.Sc. Natural Science) and Swansea (Ph.D. with J.S.Davies). She came to rest in Southampton early in 1997, working as a research fellow within the bio-organic research group of Professor Mark Bradley. Jo enjoys getting out of the lab and into the countryside, walking and climbing….Oh the weekend, always too far away.

Dr. Juergen Kress

Originally, Jurgen is from Nuernberg, Germany. He studied Chemistry at the Friedrich-Alexander-Universitaet Erlangen-Nuernberg and then stayed at the Imperial College London, as an Erasmus student, for nine months. He finished his diploma in 1996 in the group of Andreas Hirsch and subsequently completed a Ph.D. under his supervision in November 1999. His deep love of England and its people made him come here as a postdoc and so, at the beginning of the new century, he joined Mark Bradley’s group in Southampton. His main interest is of course that of every well behaving postdoc, Chemistry. Apart from that his favourite outdoor undertaking is walking and he also enjoys reading and Opera. Juergen is now working for Atotech Deutschland GmbH in Switzerland

Email: juergenkress@gmx.net

Cathy currently works for Novartis, but little else is known about this mysterious Frenchwoman.

Ian joined the Bradley group back in its very early days in October 1992 as a PhD student working on solid phase polyamine chemistry. Linker technology was developed to produce compounds for screening against the parasitic enzyme target trypanothione reductase, an enzyme unique to trypanosomes and leishmania which cause a variety of tropical diseases such as African Sleeping Sickness and Chagas' disease. After his PhD, Ian remained in the group for just over a year as a Post Doc, to develop solid phase methodology for the preparation of novel cyclic peptidic structures, such as oscillamide Y. Since May 1997, he has been working at Pfizer (UK) as a team leader in their library design and production group. Outside interests include cricket, walking, motorcycling and tinkering with old cars, plus the odd Santa Claus impersonation……

Jacqui (1972) joined Prof. Mark Bradley’s group in Southampton in Jan 2000. Before that she was at Loughborough University where she obtained her degree in Medicinal and Pharmaceutical Chemistry in 1994. She subsequently joined Parke-Davis in Cambridge, as a Graduate Medicinal Chemist for one year synthesising potential anti-epilepsy drugs. She then progressed into an industrial based Ph.D, still at Parke-Davis, which she completed in 1998. This research was based on mimetics of protein:protein interactions utilising dendrimer scaffolds. She spent the whole of 1999 in the States as a postdoctoral fellow working with Prof. Richard Silverman at Northwestern University (Chicago) in the search for further monoamine oxidase inhibitors. At Southampton, her postdoctoral research is funded by Organon (Akzo Nobel) focuses on solid phase peptide synthesis. Her interests include mostly sport, in particular swimming. In more recent years she has been dabbling in triathlon (swim-bike-run).

David was born in 1971 in Rennes (France). He passed his 1st and 2nd cycle at the University of Rennes, then he did a DEA (Master) with Dr Paul Mosset at ENSCR (school of Chemistry of Rennes). He studied the synthesis of a,a'-bifunctionnalized heterocycles.
After his national service, he moved down stairs at ENSCR and worked in Dr J.C. Guillemin's group and did his Ph.D. He researched the utilisation of zirconium organometallic complexes in organic chemistry in solution and on supports. He was awarded my Ph.D. in December 1998.
He moved away, jumped the Channel and joined Prof. Mark Bradley's group (Dept. chemistry-Southampton Univ.-U.K.) in January 1999 and is working on solid phase synthesis and combinatorial chemistry as a postdoctoral research fellow.
Other interests in life include sport (football, tennis, basket), cinema and music.

Patrick Page, was born in 1967 in Clermont-Ferrand (France), studied biochemistry and chemistry at the Universities of Clermont-Ferrand and Toulouse. His doctoral work on design, synthesis and mechanistic studies of inhibitors for class I Aldolase and Glucose transporters of Trypanosoma brucei, included asymmetric synthesis of substrates or inhibitors polyhydroxylated and hemi-synthesis (chemical and enzymatic) of fructose derivatives utilised as transmembrane vectors of the previous inhibitors, was completed in 1995 with Dr. C. Blonski at the University of Toulouse. During a postdoctoral fellowship at the University of Oulu (Finland), he worked on the design and synthesis of small organic molecules inhibitors for collagen biosynthesis, mainly focusing on the synthesis of conformationally constrained peptidomimetics containing the unphysiological 2,3-methano amino acids, including total syntheses of several ACC's, in the research group of Prof. A. Koskinen. In 1997 he joined the laboratory of Prof. M. Bradley as research fellow at the University of Southampton (England), where he worked on the solid-phase organic synthesis of polyamine conjugate analogues of Kukoamine A and Argiotoxin 636. Afterwards he investigated the solid support synthesis of libraries of peptide aldehydes for lead optimisation of serine-protease inhibitors, including the generation of libraries of moderate size (600 compounds) using "split and mix" to produce compounds with improved biological activity. Pat now works for Astra in Sweden with Bryan Egner.

In 1997, Vincent Pomel obtained his Ph.D. at the University of Rouen in the laboratory of fine and heterocyclic chemistry directed by Prof. Guy Queguiner. His dissertation topic was about the synthesis of streptonigrim analogues, a highly functionalised alkaloid used as DNA intercalants, by the associated ortho directed metalation/cross-coupling strategy. In this work, he designed a convergent strategy to emphasise structure/activity relationships in order to improve therapeutic activity against cancer and AIDS in connection with the Scientific Research National Centre (CNRS). During this work, he published two publications relating to hindered Suzuki cross-coupling reactions and one relating to a highly functionalised pyridine system.
During his Ph.D., Vincent worked for different companies. In the first year, he worked for Orgachim and he designed and carried out a chemical rejects recycling process via Deacon chlorinations. He also worked for Janssen and elaborated a convergent strategy of new 2-hydroxyquinolines. The aim of his research was to discover new leads to emphasise structure/activity relationships in the Psoriasis field. When he joined Prof. Bradley at the University of Southampton he been carryed out the synthesis of novel combinatorial libraries.
Apart from organic chemistry, he is very interested in sports, especially in football and swimming and participated in marathon races a few years ago. Fishing is also a great interest for him and he enjoys designing his own flies for troutfishing.

Dr. Pat Roussel

Patrick Roussel was born in Domfront (France) in 1963. He studied Biochemistry and Organic Chemistry part-time at the Universities of Caen and Rennes while working 7 years for the Department of Education. After graduating he carried out his doctoral work at the University of Exeter (UK) with Dr. N.J Turner and Dr L. Dinan, where he developed the synthesis of fluoro- and structural analogues of ecdysteroids and carried out their biological evaluation for structure-activity relationship investigations. In February 1996 he joined the group of Prof. M Bradley as research fellow at the University of Southampton (UK), where he developed the first solid-phase approach to the amidine pharmacophore group by means of both acid- and light-cleavable linkers. This methodology was also applied to the synthesis of the solid phase synthesis of the Novartis phase II compound CGS-25019C, and of a library of factor VIIa analogues. Afterwards he investigated a solid-phase approach to heterocyclic kinase inhibitors before joining Pharmacia & Upjohn (Sweden).
His current position in the High Speed Synthesis Method Development Group at Pharmacia & Upjohn focus on developing screening libraries, implementing combinatorial technologies and diffusing them within medicinal chemistry, and training medicinal chemists.

E-mail: patrick.roussel@eu.pnu.com

He studied at the University of Bremen, Germany, from 1989 to 1994. There, he received the degree "Diplom-Chemist" in 1994. Afterwards, he started his PhD in natural product synthesis, namely in the field of pyrrole, tetrapyrrole and chlorine chemistry. He synthesised an enantiomerically pure chlorine as building block for an artificial photosynthetic reaction centre.
Having finished his PhD in 1997, he joined an Austrian research group to do some vitamin B12-chemistry. During this period he became interested in Combinatorial Chemistry and finally decided to come to the Bradley group to Southampton.
His research interests are in the solid phase synthesis of peptides as well as the chemical modification of their C-terminal functional group for screening. Libraries of those peptides are envisaged at a later stage of the project.
In private, he enjoys learning real English, reading books, jogging and relaxing with some good beer. Last but not least, he likes to travel around with my car on the left side of the road, which is the "right" side here!

Thomas was born in 1969 in Neustadt/WN, a small town in Germany. After his national military service, he studied chemistry at the University of Regensburg (Gemany), where he obtained the diploma of chemistry in 1996.
His PhD research was carried out under the supervision of Prof. Dr. G. Maerkl (Department of Organic Chemistry, University of Regensburg) and Thomas completed his thesis in 1998 on synthesis of macrocyclic polyphosphapolyynes, possible precursors of phosphafullerenes.
In January 1998, he joined Prof. Mark Bradley`s group at the University of Southampton. His work involved solid phase synthesis of dendrimers.
When he's not doing chemistry, he enjoys tennis, skiing, football, cooking, …

Dr. Laurent Bialy

Laurent is half French, half German and was born in 1974 in the beautiful South of Germany. He studied Chemistry at the University of Karlsruhe where he joined the group of Prof. Herbert Waldmann and obtained his “Diplom” in 1998. Afterwards he moved northwards to Dortmund, where he worked at the Max-Planck-Institute for Molecular Physiology. During his Ph. D. he developed the first total synthesis of cytostatin, a natural product with anti-metastatic activity. He also synthesized some analogues and studied their inhibitory potency against various phosphatases, which disclosed a basic structure-activity-relationship of the natural product. He finally obtained his Ph.D. in 2002. Laurent joined the Bradley group in February 2003, and is now working on the field of solid-phase synthesis of PNA-conjugates. Laurent is funded by the DAAD. His interests include organic synthesis of natural compounds, bioorganic and medicinal chemistry. Besides going to the Staff club, Laurent enjoys dancing to electronic music, role-playing-games, watching and playing football.

Dr. Monika Buchholz

Dr. Baishakhi Mazumder

Dr. Selvaraj Subbiah

Dr. Michaël Ternon

Dr. Ganesh Suyal

Dr. Ganesh Suyal was a Visiting Scientist and holds a M.Sc. in Chemistry from KU, Nainital , India and a Dr. Ing. Degree in nano-composites from Institute for New Materials, University of Saarland , Saarbruecken, ( Germany ). Ganesh has over 3 years post doctoral experience in wet chemical synthesis of electro-ceramics coatings, nano-powders and nano-tubes at EPFL Lausanne, Switzerland. Ganesh has published over 15 papers in reputed international material journals and has attended several international seminars. Understanding process- property relationships of chemically synthesised materials, especially nano materials and their applications in sensors and bio-technology are the main interests of Ganesh.

He is presently running a start up company called ANKUR LIMITED and using Lab facilities of Prof. Mark Bradley. As we all know that the transparent moisture and oxygen barrier layers are needed for polymer films and plastic bottles used in food and beverage packaging industry to make food last longer and maintain its fragrance. Ankur Limited is carrying out the feasibility study and the development work on a family of noble organic-inorganic hybrid based nano-composite coatings for barrier applications. Such a development will offer low cost, easy to apply, easy to cure, transparent, environmentally friendly coatings with good mechanical behavior. Being Silica based these coatings would be much more health and environment friendly.

Dr. Jin Ku Cho