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| Former Graduate Students |

Dr. Sonia Alesso
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Sonia graduated in Organic
Chemistry in June 1997 at the Universita' degli Studi di Palermo
(Italy). The subject of her thesis was "Basic catalysis
in reaction of aromatic nucleophilic substitution. Kinetic
studies on some 2L-3 nitro-5X thiophenes with aniline in benzene";
this work was carried out under supervision of Prof. V. Frenna.
In October of 1998 she joined Prof. Bradley's group, where
she is studying towards a PhD. She is currently interested
in developing new solid supports for solid phase synthesis.
The subject of her research is sponsored by Avecia Outside
of the lab, her interests include reading books and magazines,
theatre, cinema and travelling. |

Dr. Bordin Chitkul
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Bordin was born and raised in South of Thailand. He obtained
his B.Sc. at Ramkhamhaeng University in 1988 and then he
worked in the Chemistry Department as a Research Assistant
to Prof. Apichart Suksamrarn for one year. His work was
concentrated in Natural Products Chemistry. After that,
he received a Master Degree in Organic Chemistry, under
the supervision of Prof. Yodhathai Thebtaranonth, at Mahidol
University in 1994. He wrote his thesis on the subject of
tartaric derivatives in a symmetric synthesis. He then returned
to Ramkhamhaeng University where, between 1994-1997, he
was a lecturer in the Chemistry Department. He taught Organic
Chemistry and his research group was involved in the investigation
of anti-malarial principles from the tubers of stephania
species. In 1997, he received a scholarship from the Royal
Thai Government and came to Southampton to study for a Ph.D.
under the supervision of Prof. Mark Bradley.
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Dr. Nutcha Chitkul
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Nutcha Chitkul was born in Phathalung, south of Thailand
in 1967. She obtained BSC in chemistry in 1992. She did
her fourth year project for Prof. A. Suksumrarn on investigation
of chemical constitution of vitex grabata and partial synthesis
of ecdysterriods. She worked for seven years in industry.
Her work involved polyester and alkyd resin, water and wastewater
system. She then joined the Bradley group in November 1998.
Her research project involved the synthesis of tagging secondary
amine on solid phase. She is now in her first year of M
Phil/PhD, researching proteomic, microspheres, and oligonucleotide.
Her other interests outside the lab include travelling,
reading, dancing ,and she also enjoys swimming very much.
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Dr. Mark Dixon
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Mark graduated from Leeds University
in June 1997 with a BSc (Hons) in Medicinal Chemistry. He
then worked as a chemist for Nycomed Amersham for two and
a half years before joining Prof. Bradley’s group in
Oct 2000. He is currently studying for a PhD and the subject
of his research is the development of new screening methodologies
for combinatorial libraries. Outside the lab, Mark enjoys
playing and watching football and socialising with his friends. |

Dr. Siew Eng How
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How Siew Eng was born in Malacca, Malaysia. She had graduated
with a B. Sc (Honours) and obtained a M.Sc in Chemistry
from the University Science of Malaysia , where she had
done her research under the supervision of Professor Sam
Teng Wah. She was a teacher at Matriculation Centre, University
Science of Malaysia for almost eight years before becoming
a lecturer at University Malaysia of Sabah in 1998, where
she joined the Industrial Chemistry Program, School of Science
& Technology and got involved in research on isolation
of antioxidants from natural products . She is currently
awarded a scholarship by the University Malaysia of Sabah
for a PhD studentship under the supervision of Professor
Mark Bradley. Her research is on the application of dendrimer
in signal amplification. Her hobbies are jungle trekking
and travelling.
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Dr. Karin Johnson
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Karin was born in the high coast area
of Sweden, a small town by the name of Örnsköldsvik,
some time during the previous millennium. She moved to London
1995 to undertake a Chemistry degree. In 1998 she graduated
from University of London, King’s College. Thereafter
she moved to Manchester where she worked for Professor Michael
Sinnott on a project concerning the synthesis of an inactivator
for cellobiohydrolase I. She completed a degree of Master
of Philosophy in October 1999 and joined the Bradley Group
shortly afterwards. |

Dr. Sylvain Lebreton
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Sylvain was born in France in 1974. He first obtained a technician
degree of chemistry from Paris Orsay and then decided to move
to Kingston University, in Surrey, where he got his BSc in
Chemistry in 1997. This course included a one-year industrial
training that he spent in Germany working for American Cyanamid.
He then moved to Tucson, Arizona, where he was working at
Selectide, a subsidiary of Hoechst Marion Roussel. His work
involved the design, optimisation and validation of libraries
of small organic drug-like compounds on solid phase such as
N-Amino hydantoins and Benzodiazepinones. He came back to
France in 1999 where he worked for Rhone Poulenc Rorer for
6 months focussing on the optimisation of a pyrrolidine library
on solid phase. He then joined the Bradley group in September
1999. His research project is orientated towards the synthesis
of high loading resin beads by supported dendrimerisation
for the purpose of single bead screening.
Sylvain particularly enjoys travelling and encountering different
people and cultures. He enjoys playing guitar and piano, sports,
and movies. Sylvain tries hard to keep his belly from the
beer and therefore has adopted cider rather than beer!
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Dr. Ann Jasmine Jose
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Ann Jasmine was graduated from Mahatma
Gandhi University, Kerala(India). After that she moved to
the University of Manchester to do her M.Sc. in Polymer Science
and Technology. The title of her thesis was ‘ Transition
metal complex catalysts in organic synthesis’. The work
was carried out under the supervision of Prof. P.Hodge. In
Oct. 2001, she joined Prof. M.Bradley’s research group
and began to work on ‘Biocompatible Polymers’
for AsahiKASAEI. In her free time, she enjoys cooking and
classical music. |

Dr. Iain Lingard
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Iain was born in 1976 in Birmingham where his family still
live. He studied at the University of Sheffield where he
obtained an MCHEM in Chemistry with Study in Industry. His
year out was spent working in the Medicinal Chemistry department
at the SmithKline Beecham research laboratories in Harlow,
Essex. During this time he lived in Welwyn Garden City YMCA,
a truly eye opening experience. He joined the Bradley group
in 1998 and is researching the combinatorial development
of catalysts. In his free time, Iain enjoys playing guitar,
playing and watching sports, reading, and of course going
out drinking and dancing with his friends.
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Dr. Katie McNamara
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Katie was born in 1978 in North Wales
and moved to Altrincham, Greater Manchester when she was 15
years old. She graduated with a BSc in Chemistry in July 2000
from the University of Southampton and has remained there
to undertake a Ph.D in solid phase catalysis. Her interests
include socialising, going to the cinema and aerobics. |

Dr. Mizio Matteucci
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Mizio was born in 1973 and comes from Perugia,
Umbria known as the “green heart” of Italy. He
studied and graduated in chemistry at the Universita’
degli Studi di Perugia in the field of organic synthesis in
water with Prof. F. Fringuelli. After his degree, he spent
10 months doing civil service in a small village in the National
Park of Majella, Fara San Martino which is the homeland of
one of the greatest producers of “pasta”!! He
then worked for 1 year in the organic chemistry lab of Perugia
studying Diels-Alder reactions in aqueous media. He joined
Prof. Mark Bradley’s group in March 2000 where his PhD
research is focused on peptides' solid phase synthesis. His
interests are mainly horse riding, reading, travelling and
... cooking.
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Dr. James Merrington
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James was born in Cambridge, England, in 1976. In 1995
he started his MChem at Southampton, believing local inclement
weather and nice beaches. He did his third year project
for Dr. J Kilburn on macrocyclic peptide-based receptors,
and spent his work placement with Nycomed-Amersham in Cardiff,
working on solid-phase dye synthesis. An interest in solid-phase
synthesis, fuelled by his experiences in Cardiff, led him
to a PhD in Combinatorial Chemistry with Professor Bradley
in autumn 1999. He is currently working on design and construction
of an inkjet dye library thanks to funding from the EPSRC
and Avecia. Outside the lab, his interests include hill-walking,
climbing and gastrophilia normally in that order.
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Dr. Sean Monaghan
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Seán was born in Enniskillen, Ireland in 1975. He
joined the Bradley group in September 1998, after graduating
from Queen’s University Belfast with a degree in “Chemistry
with extended studies in Europe”. This was a four
year course and involved spending one year in France at
the “Ecole Nationale superieure de chimie de Montpellier.”
His year in France gave him the opportunity to travel around
Europe and fuelled a desire to travel and see new things,
leading him to Southampton. He is funded by a BBSRC industrial
case award, collaborating with Antisoma plc, with cancer
targeting peptides and combinatorial chemistry. Outside
the lab, Seán (a big Van the man Morrison fan).enjoys
playing guitar, travelling and cooking. He also “tries”
to keep fit and enjoys Gaelic football with the local Southampton
team, Southern Gaels.
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Dr. Mathilde Muzerelle
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Mathilde was born in Seoul in 1977, South
Korea, and raised in Paris. She studied Biochemistry at the
Paris 7 University where she graduated in 1999 (similar to
a BSc and a MSc in biochemistry). During her final undergraduate
year, she spent 6 months in Stockholm, Sweden, as an Erasmus
student working on the structure resolution of the Leukotriene
A4 Hydrolase. She then moved to Strasbourg to achieve a DEA
in pharmacology and medicinal chemistry. Her project was the
synthesis of a fluorescent sensor for Inositol trisPhosphate
in Marcel Hibert laboratory, at Louis Pasteur University She
has joined the Bradley group in October 2001 and works on
the synthesis of resin-bound internally quenched fluorogenic
peptides. Besides going to the lab (of course), Mathilde likes,
her friends and cooking for them, reading, comics, going to
New Forest
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Dr. David Sampson
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David graduated from the University of Portsmouth in the
summer of 1997. His course at Portsmouth was a sandwich
degree in applied chemistry. Consequently, he worked for
a year in industry, in Medicinal Chemistry at Astra Charnwood.
He worked in the combinatorial chemistry team and subsequently
developed an interest in all things solid phase and bioorganic.
His work there was in a feasibility study into immuno-suppressants.
His final year project at Portsmouth involved the synthesis
of polymers for medical use.
This is David's third year at Southampton. In his first
year he did an M.Res. in bioorganic chemistry. The project
involved the synthesis of dehydroamino acids on the solid
phase. He is now in his second year of a PhD, researching
linker chemistry, and his work is funded by Eli Lilly.
His other interests outside chemistry include playing the
guitar, golf, motor sport, a recent interest in the "cyber-punk"
books of William Gibson, The Manic Street Preachers, alcohol,
eating, sleeping and breathing.
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Dr. Löic Le Strat
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Löic was born in 1972 in Lorient (France). He studied
at Rennes University (France), where he obtained an M.Sc
in biochemistry (1996) and a "D.E.A." of chemistry
(1998). The subject was the development of a new way to
obtain functional phospha-alkynes. He has been integrated
into the Bradley group since January 1999. He is in his
first year of a Ph.D, working on a project sponsored by
Smithkline Beecham concerning molecular imprinting of polymers.
Löic's hobbies include a strong interest in martial
arts (karate, kobudo, self-defence, tai chi chuan). He also
likes tracking and reading (especially about Far Eastern
countries). Löic's favourite food is fish, but not
with chips!
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Dr. Cecile Vitre
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Cecile was born in Saumur, a French town famous for its
wines. She started to study at the University of Angers
in Biology in 1993 before deciding to study Biochemistry
in Rennes from where she received a Master degree in 1999.
She has also worked in a University lab for a year on the
synthesis of aminoesters, potential precursors of new imidazolines
(antidepressants, antihistamines). During the summer 1999,
she joined the Bradley group as a project student. She then
started her PhD in October and is supported by Glaxo Wellcome.
During her free time, she likes cooking, walking in the
New Forest (collecting mushrooms), going to the cinema and
visiting the country.
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Dr. Neil Wells
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Neil Wells completed his B.Sc. at the University of Southampton
in the summer of 1996. During that summer he worked on the
solid phase synthesis of dendrimers as a project student
for Professor Mark Bradley. He felt that the potential of
the field was so exciting that he decided to stay and continue
the work for another year. This lead to the award of an
MRes. degree in 1997. Further details of that work are given
in the Dendrimers section.
Neil decided that he wanted to move into a different area
of research and has now dived into the field of Steroid
Chemistry. Neil's project has an exciting feel to it and
involves Dr Laurance Dinan from the Department of Biology
at the University of Exeter and the American agrochemical
company Rohm & Haas. Neil hopes to survive through the
three years of research and emerge at the end of it with
a Ph.D. degree.
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Dr. Lu Shin Wong
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Lu Shin joined the Bradley Group in September 2001 and
hails from Kuala Lumpur, the capital of Malaysia. He graduated
with a Batchelor of Pharmacy (BPharm) from the University
of Nottingham in July 1997. His final-year project involved
creating a combinatorial library of metalloprotease inhibitors
under the supervision of Dr. W. C. Chan.
After graduation, he completed his professional
training in North Wales and gained his membership of the Royal
Pharmaceutical Society of Great Britain (RPSGB) in August
1998. He then worked for the NHS as a pharmacist, first in
Plymouth and then in Doncaster. During that time, he completed
a postgraduate diploma in clinical pharmacy at the University
of Bradford.
Outside of chemistry, Lu Shin enjoys corresponding,
films, hiking, world travel and sleeping (a lot).
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Dr. Boon-Ek Yingyongnarongkul
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Boon-ek was born in Samutprakan, Thailand
in 1970. He studied at Ramkhamhaeng University where he got
his B.Sc. in Chemistry in 1991 and M.Sc. in Applied Chemistry
in 1995. The subject of his Thesis was “Synthesis and
Biological Activity of Some Ecdysteroids and Their Analogues”.
His work was carried out under supervision of Prof.Apichart
Suksamrarn. In January of 1996, he was a lecturer at Ramkhamhaeng
University and continued working on the ecdysteroid chemistry
with his supervisor. By 2000, he has published eight international
papers and two proceedings in this field. During October 1998
– September 1999, he was funded by UNESCO and MONBUCHO
to do research at Tokyo Institute of Technology, Japan under
supervision of Prof.Takashi Takahashi. He joined the Bradley
group in October 2000. His project is involved the Transfection
Agent. He is supported by the Department of Chemistry, University
of Southampton and The Ramkhamhaeng University. Outside the
lab, he enjoys playing football, reading and cooking.
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