The Bradley group has developed a number of chemistry-based approaches in which molecules can be activated (switched-on) or synthesised (generated) within biological systems by the aid of chemical catalysts.
This has resulted in several publications (Nature Chemistry: 2011, 239–243 and Nature Communications: 2014, 3277). Several novel approaches are being used in this area – namely that the tools of chemistry can be used to activate or switch-on molecules in vivo - with enormous potential application across the biomedical sciences. This includes:
• Pd mediated synthesis in vivo
• Small molecule mediated drug activation
• Light-based drug activation
This work is supported by the Rosetrees Trust, and the EU via a Marie-Curie IF fellowship.